Friday, June 17, 2011

Peau d’orange – orange peel – nephrogenic systemic fibrosis

Nephrogenic systemic fibrosis (NSF) is an uncommon disorder that occurs in kidney failure (hence nephrogenic) and involves multiple organs (systemic) that abnormally have tissue that is more fibrous (fibrosis). Because of this fibrosis, the skin of the limbs may look like an orange peel – peau d’orange.
Use of gadolinium (a metal) containing agents that are injected intravenously to enhance the appearance of magnetic resonance images (MRIs) have been associated with nephrogenic systemic fibrosis.
Piera-Velázquez S, Sandorfi N, Jiménez SA: Nephrogenic systemic fibrosis/nephrogenic fibrosing dermopathy: clinical aspects. Skinmed, 2007 6(1):24-7. Go to reference

MRI brain

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